Claudio Ventura SANTORO
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Current issues of research
1. Autoimmunome profiling - Exploiting the power of phage display technologies we developed a platform that allows the discovery and characterization of biomolecular interactions (protein-protein, protein-DNA, etc). We constructed large libraries displaying human cDNA-derived proteins and used them to profile the autoantibody repertoire (autoimmunome) in sera from patients with autoimmune diseases (e.g.: type 1 diabetes, celiac disease).
2. SINEUPs: non-coding RNAs to enhance protein translation in vitro and in vivo - SINEUPs are non-coding RNAs that are able to specifically stimulate protein translation of a gene of interest. SINEUP activity depends on the combination of two elements present in an RNA molecule: a 5′ end short sequence (Binding Domain) that complements to the sense protein-coding mRNA and determines target selection; an inverted SINE B2 sequence (Effector Domain), that is essential for protein synthesis up-regulation. We are developing SINEUP molecules to target a variety of protein coding mRNAs of biotechnological or therapeutic interests.
Top Five Papers
Mangoni D, Simi A, Lau P, Armaos A, Ansaloni F, Codino A, Damiani D, Floreani L, Di Carlo V, Vozzi D, Persichetti F, Santoro C, Pandolfini L, Tartaglia GG, Sanges R, Gustincich S. Nat Commun. 2023 Aug 17;14(1):4974.
2. SINEUP Non-coding RNA Targeting GDNF Rescues Motor Deficits and Neurodegeneration in a Mouse Model of Parkinson's Disease.
Espinoza S, Scarpato M, Damiani D, Managò F, Mereu M, Contestabile A, Peruzzo O, Carninci P, Santoro C, Papaleo F, Mingozzi F, Ronzitti G, Zucchelli S, Gustincich S. Mol Ther. 2020 Feb 5;28(2):642-652.
3. Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat. Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat.
Carrieri C, Cimatti L, Biagioli M, Beugnet A, Zucchelli S, Fedele S, Pesce E, Ferrer I, Collavin L, Santoro C, Forrest AR, Carninci P, Biffo S, Stupka E, Gustincich S. Nature. 2012 Nov 15;491(7424):454-7.
4. Di Niro R, Sulic AM, Mignone F, D'Angelo S, Bordoni R, Iacono M, Marzari R, Gaiotto T, Lavric M, Bradbury AR, Biancone L, Zevin-Sonkin D, De Bellis G, Santoro C, Sblattero D. Rapid interactome profiling by massive sequencing. Nucleic Acids Res. 2010 May;38(9):e110. doi: 10.1093/nar/gkq052.
5. Santoro C, Mermod N, Andrews PC, Tjian R. A family of human CCAAT-box-binding proteins active in transcription and DNA replication: cloning and expression of multiple cDNAs. Nature. 1988 Jul 21;334(6179):218-24.